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Thalidomide has been proved effective in reducing serum TNFα in experimental sepsis induced by endotoxins [ 10, 11] and E.coli [ 5] by a mechanism differing from monoclonal antibodies.
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For RuvB, a mechanism differing to that used by gp16 was proposed, with dsDNA rotating by the same power stroke.
We propose that the repertoire of proteins targeted by Vpr through this mechanism differs between different cell types, and specifically between T cells and macrophages, thus explaining a more potent effect of Vpr in the latter cells.
Here, we demonstrate that Daple is a new member of a family of non-receptor activators of G protein, thereby adding to the growing evidence that trimeric G proteins can be activated by mechanisms differing from classical GPCR-mediated activation.
Finally, the metabolite induces DNA cleavage primarily by a mechanism that differs from that of etoposide and appears to involve covalent modification of the enzyme.
Using SHe as a vaccine antigen induces immune protection against HRSV by a mechanism that differs from the natural immune response and from other HRSV vaccination strategies explored to date.
For instance, gene insertions of copies of storage protein genes occurred during the last 5 million years in six different locations of the maize genome, relative to the rice genome by a mechanism that differs from helitrons [ 38].
The "cut-and-paste" mechanism differs from the "permutation-by-duplication" mechanism in that it involves a momentary stage at which there are no intact, active MTase gene copies in the cell.
Products obtained by these two mechanisms differ significantly in their physical properties.
As for the role of ethnic background, some scholars state that mechanisms explaining offending are universal for all ethnic backgrounds, while others argue that these mechanisms differ by ethnic group because of cultural differences [ 1].
Available clinical data raise the possibility that stress-adaptive mechanisms differ by gender.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com