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Cushing' syndrome, a disorder that is also typified by a marked elevation in levels of cortisol, produces clinical symptomology that is similar to those observed in MetS, and they can be alleviated by decreasing circulating cortisol concentrations.
Despite complete lack of heparanase gene expression and enzymatic activity, the mice developed normally, were fertile and did not exhibit apparent anatomical and functional abnormalities, presumably because heparanase deficiency was compensated in most organs (i.e., liver, kidney) by a marked elevation in the expression of matrix metalloproteinase i.e., MMP-9 and MMP-14 family members.
Hepatotoxicity induced by carbon tetrachloride was reflected by a marked elevation of AST and ALT activities, and histopathologic alterations.
In our study, hepatotoxicity induced by CCl4 was reflected by a marked elevation of AST and ALT activities, but also by notable histopathologic alterations.
AMP/ATP ratios are significantly higher in senescent fibroblasts compared with young fibroblasts and, accordingly, in vitro senescence is accompanied by a marked elevation of AMPK activity.
The enhanced pancreatic tumorigenesis was prompted by a marked elevation in metabolic rates and energy uptake through an elevation in expression of genes encoding regulators of fatty acid uptake and oxidation.
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Following induction of sepsis by CLP, a marked elevation in serum levels of AST and ALT, a functional readout for liver damage, was observed in WT mice (Fig. 5a).
By day 4, there was a marked elevation in BAL fluid cytokine levels in all three groups.
In contrast, the genes in cluster 27 are encoded by the nuclear genome and showed a marked elevation in their expression in the heart, reflecting the high rates of respiration in this tissue.
These findings were replicated by Villar et al. They showed a marked elevation in pulmonary vascular resistance in association with reduced right ventricular cardiac index (CI) in 30 patients with ARDS [10].
These findings were replicated by Villar et al. They showed a marked elevation in pulmonary vascular resistance in association with reduced right ventricular cardiac index (CI) in 30 patients with ARDS [ 10].
More suggestions(15)
by a marked swing
by a commensurate elevation
by a marked shift
by a marked degree
by a digital elevation
by a tonic elevation
by a sudden elevation
by a slight elevation
by a marked loss
by a biphasic elevation
by a marked improvement
by a pronounced elevation
by a minor elevation
by a continuous elevation
by a marked distrust
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