Sentence examples for by a mTOR dependent from inspiring English sources

Importantly, after high oxygen exposure HIF-1α was down-modulated, but after 120 min it was partially reconstituted in GBM probably by a mTOR dependent mechanism.

This downregulation is mediated by an mTOR-dependent negative feedback loop that also involves p70S6-kinase [ 134, 142- 145].

Figure 1B shows that 4EBP1 phosphorylation and release from eIF4E are induced by serum in a mTOR-dependent manner.

Overexpression of SRSF1 and SRSF9 promote β-catenin accumulation via the recruitment of β-catenin mRNA and by enhancing its translation in an mTOR-dependent manner.

Inhibition of mTOR by rapamycin and the induction of mTOR-independent autophagy by lithium resulted in an increase in autophagy in both an mTOR-dependent and mTOR-independent manner, enhanced the clearance of protein aggregates and provided greater protection than single treatment with either of these molecules [58].

While Congdon and colleagues show an mTOR-dependent induction of macroautophagy mediated by MB [ 44], Medina et al. (2011) report an increase of chymotrypsin- and trypsin-like activities of the proteasome after MB treatment.

Given that BDNF regulates local protein synthesis in dendrites [21], [43] [45] through an mTOR-dependent pathway [21] and also induces LTP that is blocked by rapamycin [9], we examined if BDNF could be triggering mTOR activation during IA training.

For instance, rapamycin monotherapy activates Akt through inhibition of an mTOR-dependent retrograde signal [7].

This VEGF/VEGFR2 signaling cascade via VEGFR2/PI3K/mTOR induces an mTOR-dependent regulation of VEGF secretion.

TSC2 negatively regulates Notch1 signaling in an mTOR-dependent and -independent fashion.

Definitely, for IRS-1/2, a PI3K-dependent pathway, with PI3K itself acting as an IRS-1 serine/threonine kinase, appears to be involved, although IRS-2 degradation is controlled by a PI3K-mTOR-dependent mechanism.