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PanNET and Si-NET are both characterized by a low mutation rate compared to other tumor entities.
The lack of ITS variability of W. anomalus strains could be explained by the small number of sequenced isolates (n = 6), by possible clonal origin or even by a low mutation rate of the gene selected in our present study.
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The non-uniform survival rate of HD links can be explained by assuming a low mutation rate for a high-degree node, and thus this model appears to be biologically plausible.
This argument is strengthened by the recent finding of a low mutation rate and a low incidence of BPS in the thermophilic bacterium, T. thermophilus [33].
The low diversity in the Giant Squid is believed to be due to a recent bottleneck followed by expansion, possibly coupled with a low mutation rate [ 34].
Furthermore, the lack of a long-lived dauer "seed bank" in C. elegans implies that populations cannot be reconstituted by quiescent stage larvae with a low mutation load.
Clear cell renal cell carcinoma (ccRCC), the most common form of renal cell carcinoma, is characterized by a relatively low mutation rate with few mutations shared among patients.
Pleuromutilin was characterized by a low spontaneous mutation frequency of 10−9-10−10 againS. S. aureus and other organisms tested [ 17].
In general, fishes are characterized by very low mutation rates and sturgeons have one of the lowest mutation rates within all vertebrates [ 35].
SNPs are characterized by low mutation rate and low probabilities of back and parallel mutation, making SNP analysis suitable for tracing early demographic events in human history.
The control population CAp35, obtained after 35 serial cytolytic infections of clone MARLS in cell culture in the absence of mutagen, shows a characteristic tree with evident lower diversity than the populations treated with mutagen, as documented by the very low mutation frequency value (12-fold smaller than population RAp35, see Table 1), and the average shortness of all the branches.
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