Sentence examples for by a low affinity from inspiring English sources

However, the anti-CRLuc antibody developed in this study will allows addressing the question whether low luminescence in the assay is caused by a low affinity of the protein pair or low levels of the protein accumulation in one or both of the protein pair as discussed in the following sections.

ApoA-I binding to ecto-F1-ATPase induces the hydrolysis of ATP to ADP which in turn activates HDL endocytosis by a low affinity receptor that remains to be identified (Fig. 1).

In a rat model, the low in vivo potency of RA was explained by a low affinity to the μ-opioid receptor in combination with a poor brain penetration [ 12].

The main transporters involved in the uptake of Ca2+ into mitochondria is the MCU, characterized by a low affinity for Ca2+; in fact, MCU takes up Ca2+ in the micromolar range and experiments in permeabilized cells report a K d of the uniporter of 10 μM [ 40].

Glucose is transported inside pancreatic beta cells via several transporters and undergoes phosphorylation by the enzyme glucokinase, a specific form of hexokinase characterized by a low affinity to glucose and lack of inhibition by the product of catalyzed reaction, glucose-6-phosphate [ 34, 35].

A recent binding study using homogenates from AD confirmed human tissues and their control counterparts also indicates the presence of multiple binding site models for the amyloid tracers23, wherein [18F]-AV-45 [18F]-AV-45 [18F]-AV-45 shown to bind to two different binding sites, andigh-affinity site (visualized by PET) and a low affinity site.

These are: the cytochrome bo3 type quinol oxidase (encoded by cyoABCD), which has a low affinity for O2, and the high-affinity bd-type cytochrome oxidase (encoded by cydABCD).

Currently, no Cd-specific influx transporter has been reported for plant cells, however, transport can be realized by ZIP transporters, albeit at a low affinity; ZIP transporters have a highly specific transport affinity for Zn or Fe [ 33].

In the actin+ state, the ATP-binding pocket has an open conformation characterized by a low-affinity towards ATP.

Ammonium is taken via two high-affinity permeases (Mep1p and Mep2p) as well as by a low-affinity permease (Mep3p).

Mitochondrial calcium uptake is mediated by the negative mitochondrial membrane potential and by a low-affinity calcium uniporter.