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Adjacent blades are connected by a loop bridging from strand D on one blade to strand A on the next.
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These two regions were connected by a loop.
For example, the player can create strong wind by drawing a loop, cut enemies by drawing a line through them or fix bridges by painting on the broken one, amongst many other abilities.
In the structurally related FKBP13, this loop crossing is stabilized by a disulfide bridge linking the two loops [ 47].
The conformation of the α7M α8M loop is stabilized by a salt bridge between Arg1682 and Glu1690 inside the loop, enabling polar and nonpolar contacts with the α2A helix.
We can cite disintegrin, like applied model, in which we can note a loop accessible stabilized by disulfide bridges [ 78].
Contradicting all assumptions, the structure reveals an active site enclosed by a flexible loop with two Zn2+ ions bridged by a carboxylated lysine and a third Zn coordinating a rare histidinate ion.
Nonetheless, it appears that both ends of the AB loop are tied together, either by a salt bridge as in GG-SpaD (Fig. 2b) or by a disulfide bond as in corynebacterial SpaA32 (Fig. 10d).
In addition, the active-site pocket of Class II members is partially occluded by a disulphide bridge between the flexible and catalytic loops (Fig. 9a), which restricts the accessibility and size of the substrate [ 7, 8].
One of the major interactions in the model structure is thereby formed by a salt bridge between Asp104 and Arg170 upstream of loop 165 (Fig. 3B).
Thrown for a loop by a coworker?
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