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Peptide-based approaches to mimicking protein interactive regions have relied mainly on linear peptides; however, most binding sites are discontinuous and thus not easily reproducible by a linear sequence.
Typically, the HSP72 binding motif can be defined by a linear sequence of 7 amino acids containing hydrophobic side groups or aromatic rings (1).
Likewise, the lipid binding site of Plin2 may also be defined by the tertiary structure of the protein and may not be easily described by a linear sequence motif.
By integrating the Vf2.1.Cl signal over N = 5 carrier wave cycles (10 s), we detected intercellular connectivity down to (at least) 10th order cells (i.e. to cells that were separated from the stimulated cells by a linear sequence of 10 adjacent neighbors), in wild type cultures.
The N-terminal domain 1 is responsible for recognition of the codon in the A-site of the ribosome and the most recent evidence suggests that the recognition is not by a linear sequence of amino acids but rather distinct motifs that are close together in the three-dimensional structure of the protein.
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The gameplay mostly relies on figuring out a way to help other characters by completing a linear sequence of challenges.
The experimentation has been carried out in an isothermal integral reactor by working with a linear sequence of temperature time.
We had suggested that upstream the activation of Epac by cAMP there is a linear sequence of reactions; downstream of cAMP/Epac the pathway bifurcates into two limbs.
Telomeres play two important roles: (1) they serve as substrates for telomerase and thus prevent the loss of sequences at the very end as would be expected for a linear sequence replicated by semi-conservative DNA replication.
Secondary and tertiary structures of RNA predicate function, and because these rules also apply to RNA, with the substitution of U for T, it is possible to predict potential secondary structures from a linear sequence of RNA by identifying putative base-pairing partners (Leontis and Westhof, 2001).
He calls for making history more legible within this crowded urban setting by linking the 9/11 memorial, "Reflecting Absence," to a linear sequence of historic sites.
More suggestions(16)
by a consistent sequence
by a linear storyline
by a linear state
by a linear scale
by a linear compressor
by a linear fit
by a linear cause
by a linear element
by a linear imaging
by a linear park
by a linear equation
by a linear control
by a linear relationship
by a linear superposition
by a linear transformation
by a linear combination
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