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Furthermore, haematological toxicity, like tumour response, is a deterministic effect of radiation, characterised by a sigmoid rather than by a linear dose relationship [ 93].
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Addition of Pt to neutrophils was accompanied by a lag phase of about 1 min, followed by a linear dose-related increase in LECL, which peaked at around 4 min and achieved statistical significance at concentrations of 0.025 μM Pt and higher.
Individual patient data were characterized by a linear dose-dependent increase and an exponential decay function describing repair.
This possibility that certain Key Events might be best characterized by a linear dose-response curve and others by a nonlinear curve could be examined in a comprehensive analysis of Key Events for L. monocytogenes.
A linear dose response was not seen.
Japanese A-bomb survivors exhibit a linear dose response for solid cancers up to about 3 Gy; at higher doses transformation is significantly reduced by cell killing [ 16].
Using a linear dose response for all leukaemias as a group, the ERR changed by 0.12 per 100 mGy increase in TRDS-2009 dose (95% CI 0.04 0.25; P<0.001).
As argued earlier, 16) DNA binding by Cr III) complexes predicts a linear dose-dependence between cellular Cr VI) and mutagenic Cr-DNA adducts.
The lack of a linear dose-response relationship as addressed explicitly by Schmidt et al. [1] also does not invalidate the observed phenomenon.
A linear dose-response slope (DRS) was calculated as the percentage decrease in FEV1 at last dose divided by the total administered dose [ 21].
For NPI-2, a linear dose-response relationship was demonstrated.
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