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For that purpose, mice were intranasally immunized with recombinant EA1, followed by a lethal challenge of B. anthracis spores.
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Finally, the active and passive immunization studies indicate that the epitope defined by 11B7 is protective against a lethal challenge of F. tularensis LVS in mice.
IL-23 deficient mice were not protected from a lethal challenge by IsdB vaccination, pointing to a critical role for CD4+ Th17 in IsdB-mediated vaccination.
The most direct means of evaluating vaccine efficacy in mice is to assess protection by monitoring weight loss and death rates after a lethal challenge of Ebola [43].
Mice that were immunized with the attenuated virus by the respiratory route were also significantly protected from a lethal challenge with wildtype virus.
In a study conducted by Haziot et al, CD14-deficient mice were not only resistant to a lethal challenge (5×106 cfu) of Escherichia coli 0111 B4, but also had a 27-fold lower level of bacteremia in the blood [49].
The default response to a lethal challenge is to threaten back.
Upon immunization with self-adjuvanted SAPNs, mice were completely protected against a lethal challenge.
Moreover, these animals were protected against a lethal challenge with RHDV.
Moreover, immunization with M2e peptide could protect mice from a lethal challenge with influenza virus.
induces cross-protective immunity in mice against a lethal challenge with H5N1 virus.
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