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However, these findings need to be confirmed or refuted by a large randomized placebo controlled trial.
These results, although interesting, need to be validated by a large randomized, double-blind, placebo-controlled trial.
To date, drotrecogin alfa (activated) is the only therapy that has been demonstrated to be efficacious in severe sepsis by a large, randomized, double-blind, placebo-controlled trial.
24 The clinical benefit of losartan was demonstrated by a large randomized controlled trial aiming to compare the efficacy of a losartan-based regimen with that of an atenolol-based regimen.
The effect on sensitivity and recall rates of radiologists using this interactive CAD system for real-life screening can only be determined by a large randomized controlled trial in which radiologists use this system during routine use and for a substantial period [ 17].
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Unlike other pharmacologic treatments APC has been shown to reduce 28-day mortality by 6.1% in a large randomized controlled trial (RCT) in severe sepsis [ 10].
This retrospective study reports the APACHE II scoring error rates for three case scenarios calculated by Clinical Research Associates and Research Coordinators involved in a large randomized placebo-controlled critical care clinical trial.
Finally, we will argue that this paradigm is now challenged by the findings of a large randomized controlled trial in septic children.
We therefore wished to gain a broader picture of the utility of measuring HIV-1 DNA levels by studying participants in a large, randomized trial of primary HIV-1 infection.
Still, a treatment-associated incidence density of 1/1,000 is acceptable, considering that bisphosphonate treatment is likely to reduce the incidence density of any fracture by 15/1,000 according to a large randomized trial (Black et al. 1996).
This theory has already been challenged by the results of a large randomized controlled trial which failed to prevent oedematous malnutrition in susceptible children with anti-oxidant supplements [ 11].
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