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Detailed mapping of BTA23 by radiation hybrid analysis [ 43, 45] suggested that the ancestral MHC was likely disrupted by a large inversion that produced the bovine MHC class IIa and IIb regions.
As described previously [ 13], these two chromosomes are distinguished by a large inversion that terminates in oppositely transcribed NME gene paralogues, consistent with it being due to unequal recombination.
Other molluscs like the gastropod Haliotis rubra [ 40], the polyplacophoran Katharina tunicata [ 26] and the cephalopod Octopus vulgaris [ 41] show a similar gene order, but distinguished by a large inversion of about half the mt genome.
The identification of the two large contigs was later independently confirmed by a prepublication draft sequence from the Broad Institute (GenBank accession number ABJH00000000), although our assembly of the 6.8-Mb replicon differed from theirs by a large inversion at virtually identical rRNA operons (supplementary fig. S2, Supplementary Material online).
Other molluscs, like the polyplacophoran K. tunicata [ 14], the gastropod Haliotis rubra [ 51] and the cephalopod Octopus vulgaris [ 52] show a similar gene order, but are distinguished by a large inversion of about half the mt genome (Additional file 1: Figure S1).
Similar(55)
We investigated these alternative regulatory strategies by engineering a large inversion that precisely separates the murine HoxD complex from its centromeric neighborhood.
The BM407 chromosome is collinear, with the exception of a large inversion (nucleotide 600371 to 1416050).
This indicated the presence of a large inversion comprising about half of the Z chromosome.
We described for the first time a large inversion in a linkage map of octoploid strawberry.
A large inversion of a group of markers was detected in LG7 of Pic.
However, our dot plot sequence alignment for this region is less complex and shows a single, smaller inversion inside a larger inversion.
More suggestions(16)
by a large contrast
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by a single inversion
by a second inversion
by a large number
by a vial inversion
by a large audience
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by a transpressional inversion
by a paracentric inversion
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by a mathematical inversion
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