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It seems that low correlations or effect sizes are only published by journals if the results are justified by a huge sample size; high correlations or effect sizes are published even if the sample size of the study is small.
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However, it has to be noticed that the increase of risk found by Koutros et al was very modest and could therefore be detected only by a study with a huge sample size, such as BPC3.
An accurate picture needs a huge sample.
Not a huge sample, but even so, Ms. Robbins's conclusions are hard to quarrel with.
Also, both Duke and Ardais note that tissue is valuable only as part of a huge sample set.
There really was no shame with sampling in this era -- throw a huge sample over some breaks and you have a rave hit.
Moreover, they need a huge sample size for acceptable performance [ 4, 5].
A huge sample size would therefore be required to demonstrate a significant excess of allele sharing over Mendel's law.
To demonstrate the superiority of intravenous versus oral PPI treatment, a trial with a huge sample size was required.
IRT models also need a huge sample size to guarantee accurate item parameter estimates [ 1, 2, 4].
Using existing resources such as birth registry data, can provide data on a huge sample of spontaneous births.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com