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USPC represents a variant of endometrial carcinomas characterised by a highly aggressive biological behaviour.
Glioblastoma multiforme (GBM) is still the most frequent primary brain tumor in adults and is characterized by a highly aggressive phenotype [ 1].
Histologically similar to high grade ovarian cancer (Carcangiu and Chambers, 1992; Sherman et al, 1992), USPC has a propensity for early intra-abdominal and lymphatic spread even at presentation (Carcangiu and Chambers, 1995; Goff et al, 1994) and is characterized by a highly aggressive biologic behaviour (Carcangiu and Chambers, 1992; Goff et al, 1994; Sherman et al, 1992).
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These proteins have a known regulatory role in metastatic process, as demonstrated by the silencing of MED15 that decreases the metastatic potential of a highly aggressive BC cell line by reducing TGFB/Smad signaling [ 74].
SCC of the esophagus (SCCE), characterized by McKeown [2] in 1952, is a highly aggressive malignancy that accounts for only 0.4%to3.1%1% of all esophageal malignancies [3]– [3]].
Approximately 15 20 % of breast cancers show a highly aggressive subtype, characterized by epidermal growth factor receptor 2 (ErbB2) overexpression.
Primary small cell carcinoma of the esophagus (SCCE) is a highly aggressive disease characterized by early dissemination and poor prognosis.
Hepatocellular carcinoma (HCC) is a highly aggressive tumor characterized by its lack of response to conventional chemo-, rando-, and immunotherapies [ 1].
This solution corresponds to a highly aggressive medium not only by the coupling of two aggressive agents, but also by a high concentration of S2− (320 ppm).
Regarding the propensity to engage in IGP, the ranking is reversed, with A. andersoni being a highly aggressive IG predator, followed by the intermediate N. californicus.
Adult T-cell leukemia (ATL) is a highly aggressive human leukemia characterized by the clonal proliferation of mature T cells and is initiated by an infection with human T-cell leukemia virus type 1 (HTLV-1) [ 1, 2].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com