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FST is generally influenced by a high mutation rate and it might be difficult to compare FST in markers with different mutation rates: the FST of microsatellite loci and the FST of SNPs.
We also observed that in our cohort heteroplasmies tend to occur in positions characterized by a high mutation rate.
The expansion of amino acid repeats is determined by a high mutation rate and can be increased or limited by selection.
The high intraspecific clonal diversity and the patterns of paraphyly at the mitochondrial DNA in B. kissophila might be explained by a high mutation fixation rate and past hybridization events.
Even so, the host cell must have had nearly insurmountable problems in getting through its life cycle, faced as it was by a high mutation rate from the bombardment of genes and introns, variable numbers of now straight chromosomes, and presumably, an inability to divide by the standard archaeal chromosomal segregation.
However, until now, vaccines have not been successful in protecting against pathogens characterized by a high mutation rate, such as HIV and HCV that are able to evade the antibody response by modifying their target antigens during the course of infection.
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The empirical populations therefore evolved a genotypic resiliency despite a high mutation rate by adopting the characteristics of quasispecies, implying that primordial RNA pools could have used this strategy to avoid extinction.
Continued proliferation will make the cells susceptible to a high mutation rate, accompanied by massive cell death.
Scofield and Schultz (2006) found that large plants have a higher inbreeding depression than smaller plants, which is probably explained by a higher mutation rate per generation.
But such phenomenon can be explained by a higher mutation and recombination rates within those regions that lead to decreased sequence repetitiveness and lower opportunity for replication slippage to occur (Kruglyak et al. 1998; Ellegren 2004).
In general, the mdTE/hdTE ratio is expected to range from 0 to 1 due to a faster elimination rate of non-essential DNA in mouse than in human, driven by a higher mutation rate in rodents than in human [ 13].
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