Finite element analysis has the potential to assist in the design process by refining a given intervention or identifying an optimal intervention without having to actually build and test each condition.
These pragmatic designs often incorporate the concept of plausibility instead of probability, aiming to construct a strong argument that a measured effect is unlikely to have been caused by inputs outside a given intervention.
Such an approach might start with small, rapidly implemented and brief (60 days or less) translational clinical trials of biomarker modulation by multiple doses of a given intervention, alone or in combination with other mechanism-based agents.
They plot the impact on GHG emissions of different interventions in the order of cost-effectiveness thereby allowing the user to visualise the cost (or savings) of reducing emissions by a specific amount using a given intervention.
Indicators cover the roles of all those involved (supervisors, anchor personnel as receivers and providers, targets), in each intervention-related groups (IRG: basic setting in which a given intervention is planned by the programme and may differ in implementation level) and for every intervention period.
Also, because of the hyperbolic nature of the power-duration relationship of a constant workrate exercise test, the magnitude of improvement in endurance time following a given intervention will be influenced by its baseline pre-treatment value: the longer the pre-treatment endurance time, the larger the post-intervention improvement [14].
Finally, we estimated the probability that a given intervention will meet the CEA decision criterion, and hence, will be the optimal intervention, by calculating the CEAC.
Moreover, this process will help to clear any lingering questions about defining what is meant by "integration" for any given intervention that is implemented and evaluated, and thereby strengthen the evaluation and the resulting evidence base.
Also, we will blind the patients by not telling them the given intervention, and prior to intervention we will explain to them why it is important that they are retained from this information.
