Thus, in this case, we can consider a simpler, easily computable estimation method for parameters of the logistic regression model without the interaction term, and if the likelihood for a given combination by that model is high enough, this combination can be pruned.
The invariance to average enzyme levels allows one to address this question in a general way, namely by asking what enzyme profile minimizes a given combination of static and dynamic enzyme-associated cost.
The MVH system segregates experimental peaks into three intensity classes and measures the point probability of matching a given combination of peaks by random chance using a multivariate hypergeometric distribution [17].
Much of previous work on distance measures in computational biology focused on such properties as metric and additive [ 3, 4], which have a close connection to the computational tractability of the clustering algorithms, but, generally, are not designed to tell anything about the biological plausibility of the groups of genes generated by any given combination of measure and algorithm.
The center of mass calculations were used to estimate the phenotypic center for each metabolite that was significantly affected by the given combination of loci.
Genotypes were added sequentially in order of likelihood ratio (or equivalently by the absolute risk conferred by a given genotype combination estimated using Bayes' formula).
TGF-β-induced gene responses are thus classified by groups of genes that are jointly controlled by a given Smad cofactor combination (Shi and Massagué, 2003).
Indeed, only 60-80% of our positive samples could be verified by a given alternative technique while only the combination of all data derived from the various tested HPV detection methods would confirm our (MY09/MY11//GP5+/GP6+ -nested PCR-based results, therefore supporting our data as not being false positives.
If HER2 expression in PDA cells could be enhanced by treatment with a given agent, then combination therapy with that agent and trastuzumab emtansine (T-DM1), a chemotherapeutic agent that is a conjugate of trastuzumab, might lead to significant antitumor effects against PDA.
