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Postsleep wakefulness, compared to presleep, is characterized by a generalized decrease of higher beta-1 and beta-2 EEG power over almost all scalp locations.
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Taken together, studies show that both preterm and full-term children with neonatal intensive care unit (NICU) experience display greater perceptual sensitization to tonic heat (Hohmeister et al., 2009) accompanied by a generalized decreased sensitivity to cutaneous thermal (Walker et al., 2009a) and mechanical (Schmelzle-Lubiecki et al., 2007) stimulation.
This hypothesis has been strengthened by findings that hypertensive subjects experience a generalized decrease in β-adrenergic responsiveness, which modulates the development of obesity in hypertension [ 41, 42].
The decrease of streamflows during the second half of the Twentieth Century in the Iberian Peninsula may accelerate in coming decades, as future climate projections show a generalized decrease in precipitation and more evapotranspiration induced by higher temperatures.
RYGB is also associated with a generalized decrease of white blood cell and platelet counts accompanied by significant anemia.
DEXA analysis of the lumbar spine revealed a generalized decrease (59%%) in bone density.
Alkhalil et al. described a generalized decrease in host mRNA levels 3 and 7 hours after MPV infection of Macaca mulatta kidney epithelial (MK2) cells.
A DEXA analysis of lumbar spine and the right hip region revealed a generalized decrease in bone density.
By contrast, we observed no significant decreases in the expression of other genes involved in maintaining the differentiated function of β cells, including Pdx1, nor in SUR1 (ABCC8) or glucokinase (Gck; Suppl. Fig. 1), nor in neuroD1 or MafA (LKB1 fl/fl.RIP2.Cre + vs. LKB1 fl/+.RIP2.Cre+, not shown) suggesting that a generalized decrease in β-cell differentiation did not occur.
Thus, part of the chemopreventive efficacy of antiestrogens and retinoids in this model may be due to a generalized decrease in ductal development.
As discussed in the introduction to this section, this toxicity can be manifested in bone marrow suppression and pancytopenia, a generalized decrease of blood cellular components.
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