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The two half-sites, inverted with respect to one another, are separated by a four base-pair center sequence that the endonuclease does not directly contact.
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In the absence of elongation, a four base-pair helix II capped by a UUCG apical loop exhibits a higher degree of order compared to a six base-pair helix I (theta(I /theta II)=0.56+/-0.1).
Foldback elements carry long terminal IR arms from several hundred to a thousand base pairs long separated by a spacer of variable length.
The different SSCP patterns observed are caused by one to four base-pair polymorphisms (26 ).
Recent genomic sequencing of Mtb H37Ra has shown that the sequences of phoP in H37Ra and H37Rv differ by one base-pair: cytosine to thymine at position 656.
When the upper end of the B-DNA model shown in Figure 8 is extended by four base pairs, a steric clash will result between the left wall of the minor groove and the upper left bipyridine ligand.
In addition to the original 11-mer index of BLAT [47], EvoPrinterHD indexes each genome into a second set of non-overlapping 11-mers, offset by four base pairs from the initial indexing, and into a third set of non-overlapping 9-mers.
In addition to the original non-overlapping 11-mer genomic index of BLAT [ 6], EvoPrinterHD indexes each genome into a second set of non-overlapping 11-mers, offset by four base pairs from the initial indexing, and into a third set of non-overlapping 9-mers.
The two catalytic sites related by the heterotetramer two-fold axis are separated by four base-pairs and each catalytic site contains one quinolone molecule (Figure 6A and B).
Juveniles that exhibited a single mismatch, involving a single allele that differed from a parental allele by a single repeat unit (four base pairs in this study), were assigned to the family for which six of seven loci matched.
The biochips could resolve a mixture of fully complementary five base-pair mismatched targets by the location of binding on the surface.
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