Sentence examples for by a flexible polypeptide from inspiring English sources

A large number of resolved x-ray crystal structures indicate that bPBP is composed of two domains connected by a flexible polypeptide linker that allows the protein to cycle between open and closed conformations.

These molecules are comprised of variable heavy (VH) and variable light (VL) chains of an antibody that are joined by a flexible polypeptide linker (Monnier et al. 2013; Nelson 2010).

ScFvs consist of a single polypeptide chain, comprising an antibody heavy chain variable domain (VH) associated by a flexible polypeptide linker to a light chain variable domain (VL) [20], [21], [22].

The smallest format found to keep full binding activity is the so-called single-chain fragment (scFv), in which the two variable regions, VH and VL, are artificially linked by a flexible polypeptide [12] [15].

The two domains are connected by a flexible polypeptide linker rich in serine and threonine residues that are O-glycosylated.

These small scFvs consist of a variable heavy chain (VH) and a variable light chain (VL) linked together by a flexible polypeptide linker [ 3].

Single-chain Fv antibody fragments (scFv) are polypeptides in which the variable domains of immunoglobulin heavy (VH) and light (VL) chain can be connected via a flexible polypeptide linker (Bird et al. 1988).

The N-terminal membrane anchor domain structure has been solved in its myristoylated and non-myristoylated forms showing a flexible polypeptide chain with two helical structure elements [ 15].

Chan et al. synthesized a recombinant protein VEGF composed of VEGF165 fused through a flexible polypeptide linker (GGGGS 3 to the n-lobe of human transferrin (hnTf) for imaging angiogenesis [ 36].

By a combination of two magnetic resonance methods, electron paramagnetic resonance and nuclear magnetic resonance spectroscopy, we demonstrate that the OPN ensemble exhibits not only characteristics of an extended and flexible polypeptide, as expected for an IDP, but also simultaneously those of globular proteins, in particular sigmoidal structural denaturation profiles.

While we have recently developed a strategy for attaching arsenicals to flexible polypeptide chains, here we explore the design and implementation of simpler reagents that might serve as prototypes for membrane-permeant derivatives.