Sentence examples for by a flexible loop from inspiring English sources

This proposed binding mechanism for integrase inhibitors involves interaction with a specific Mg2 + in the active site, accentuated by a hydrophobic interaction in a cavity formed by a flexible loop upon DNA binding.

Contradicting all assumptions, the structure reveals an active site enclosed by a flexible loop with two Zn2+ ions bridged by a carboxylated lysine and a third Zn coordinating a rare histidinate ion.

A comparison of the Mtb AcpS structure determined here with those of other AcpS proteins revealed unique structural features in Mtb AcpS, namely, the presence of an elongated helix followed by a flexible loop and a moderately electronegative surface unlike the positive surface common to other AcpSs.

The two models were linked, as reported in Methods, by a flexible loop and subjected to molecular dynamics simulation.

The NBD94566 663 molecule with its long N-terminal and shorter C-terminal α helices, linked by a flexible loop, shows a hinge-like arrangement (Fig. 6B).

17, 18 MSK1 contains two kinase domains separated by a flexible loop segment.

Like dynein, Lis1 acts as a dimer, with each monomer comprising an N-terminal dimerization domain (LisH) followed by a coiled-coil, a flexible loop and a C-terminal β-propeller domain of 7 WD motifs (Kim et al., 2004; Tarricone et al., 2004).

In a study by Lan [41], the presence of a flexible loop near the active site of Glo1 was proposed which was specified later on by Creighton and coworkers [24] (Figure 5).

The G1 motif, defined by the consensus element GxxxxGK [ST], forms a flexible loop which interacts with the phosphate group of the nucleotide [ 10- 12].

The few observable signals are likely generated by some highly mobile region(s) of SP-A undergoing fast motion (e.g., a flexible loop).

Class II Sphingomyelinase D presents an additional intrachain disulphide bridge that links a flexible loop with a catalytic loop.