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The syntactic frames associated with the individual lexical items are unified by a dynamic binding process into a structural representation that spans the whole utterance.
Gfi1b is not atypical, either in terms of the number of peaks or the degree of TF interchange on differentiation, as judged by a dynamic binding complexity scoring matrix (see Figure S3B; Supplemental Experimental Procedures).
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Transcription is regulated by the dynamic binding of TFs to the underlying DNA sequences in a cell type-specific manner [ 3].
Abeles, M., Hayon, G. & Lehmann, D. Modeling compositionality by dynamic binding of synfire chains.
Zaret, K. S., Lerner, J. & Iwafuchi-Doi, M. Chromatin scanning by dynamic binding of pioneer factors.
Interaction between miRNAs and long noncoding RNAs or transcribed pseudogenes has also been reported [ 21, 22]; such transcripts, along with mRNAs [ 23, 24], can reciprocally control the level and function of miRNAs by dynamic binding to the same miRNA [ 25].
To check the existence of a ligand receptor dynamic binding equilibrium, we used SCCF.
The novel approach used does not simply model the output of a known architecture but infers the logic of regulatory interactions between TFs, by incorporating topology and dynamic binding behavior derived from TF-binding data and using high-resolution gene expression profiles to supervise the search for the best solution.
Structural studies reveal that the specificity of the BAH domain for H4K20me2 is mediated by a dynamic aromatic dimethyl-lysine-binding cage and multiple intermolecular contacts involving the bound peptide.
The diversity in the types of gene regulation carried out by PPARβ/δ is consistent with dynamic binding and interactions with chromatin and indicates the presence of complex regulatory networks in cells expressing high levels of this nuclear receptor such as keratinocytes.
I further confirmed the occupancy of MKL1 and ELK4 on different target genes by ChIP-qPCR and also compared the dynamic binding of MKL1 and ELK4 before and after zymosan treatment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com