Sentence examples for by a double mutation from inspiring English sources

Because removing charges by a double mutation cycle mainly discloses the immediate charge charge effect, mutational analysis tends to overestimate the overall energetic contribution of salt bridges to protein stability.

Furthermore, overexpression of presenilin-1 lowers Pen2 promoter transactivation, a phenotype abolished by a double mutation known to prevent presenilin-dependent gamma-secretase activity.

The results are consistent with those reported for the mutant C-terminal domain of PB2 fused to GFP [10] and indicate that nuclear accumulation of untagged PB2 protein is slightly affected by single-point mutations in NLS1 and more inhibited by a double mutation in NLS2.

The changes of gene expression induced by a double mutation, however, were more extensive, which may indicate synergistic effects on transcriptional regulation.

Strengthening of the weak pyrimidine tract of exon 16 by a double mutation, resulted in full exon 16 inclusion, suggesting that its incorporation depends on efficient recognition of the splice sites.

Ferret models suggest that virulence is not increased by adamantane resistance in influenza A (H3N2) infections (8 ), although experimental studies with recombinant influenza (H1N1) in mice have suggested that the mortality rate is increased by a double mutation conferring adamantane resistance (9 ).

The middle and right panels show the epistatic interaction between a single mutation and a double mutation (joined by a hyphen).

A double mutation p.R776G/p.L858R was found by Wu et al [ 30] and the patient harbouring these two mutations did not respond to tyrosine-kinase inhibitor therapy.

These mice overexpress human APP695 with a double mutation KM670/671NL.

A double mutation was found in two isolates.

One case showed a double mutation in exon 3.