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Significantly, the phase 2 response in neuroblastoma cells due to CDDO-MA was translated functionally by a dose dependent increase in cellular GSH production, one of the major cellular antioxidants under the regulatory control of Nrf2/ARE signaling [20].
The specific activity of IDE on T40 was demonstrated by a dose dependent inhibition with insulin (a natural IDE substrate) or 1,10-phenanthroline (a zinc metalloprotease inhibitor)(Figure 2B).
Dead animals showed extensive uptake of SYTOX® Green that was accurately detected by the imaging system (Figure 3J L), as was shown by a dose dependent increase in the number of dead animals that correlated with the number counted manually (Figure 3N).
Activation of the complement cascade was evidenced by a dose dependent elevation of peak C3a values (fixed dose 9.1 (SEM = 0.6); esc.
Crosstalk between gangliosides and IL-6 also held in the reverse direction as demonstrated by a dose dependent decrease in GM3 in cells incubated with exogenously-added IL-6.
Signs of inflammation were detected after collagenase injection, denoted by a dose dependent increase in the difference between the ipsilateral and contralateral knee diameter at one week, significant only for the 500 U dose (P <0.001, Figure 1), with ipsilateral joint diameters returning to contralateral values thereafter.
Similar(54)
Ethyl acetate extract of F. mollis reverted the hyperglycemia and hyperlipidemia caused by dexamethasone in a dose dependent manner.
Interestingly, the interaction was moderately inhibited by PS in a dose dependent manner.
The effect of TMP was significantly enhanced by GEN in a dose dependent manner.
Sera from vaccinees could be shown to recognise the native PfAMA1 by immunofluorescence in a dose dependent manner.
The expression of the pancreas marker Nkx6.2 is also blocked by AGN193109 in a dose dependent manner (Fig. 4H K).
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