If the inhibition of XBP1 splicing by CS is a dominant effect then the observed ability of UPR-inducing agents to promote splicing should also be compromised.
Furthermore, we have shown that the Th2 response induced by epicutaneous immunization exerts a dominant effect over CFA-induced Th1 responses by interfering with the development of systemic antigen-specific Th1 responses and skewing established Th1 responses towards Th2 [6].
Thus, it is not known whether the net increase in histone H3 acetylation and/or a dominant effect by the deacetylation/methylation of H3K27 plays a major role in the negative regulation of the TSHα gene.
The results are very similar to those obtained with the assumption of a dominant effect by 1298C (Table 5).
To determine whether the defect in virus assembly observed with attB-Ad was due to a dominant effect mediated by the attB sequence we generated a new Ad construct named Ad5/FC31.1 with a second packaging domain inserted at the right-end of the genome (Figure 1).
Although clusters of nuclei indicated syncytial myotubes in the field of view, cells expressing EB3 shRNAs did not participate in cell fusion, suggesting that depletion of EB3 had a dominant effect, probably by interfering with the acquisition of fusion competence.
We compared proportions of mutant embryos and adults in experimental crosses to those expected if BE, Fr and Spr phenotypes were caused by embryonic recessive lethal alleles with a dominant effect on eyespot pattern.
Celsr1 Crsh mice have a more severe phenotype than a Celsr1 knockout null allele (Ravni et al., 2009; Qu et al., 2010), encouraging the view that Celsr1Crsh mutant protein might also exert a dominant effect, for example by binding interactors and blocking their function.
Since the defects we observed were consistent with being caused by a dominant maternal effect, and since a dominant maternal effect locus, Accordion, had previously been described to map in the region 24F1-24F4, we tested alleles of genes in this region for their gastrulation phenotypes.
As a result, the aggregate conformations might be strongly affected by a dominant electrostatic effect of the termini.
