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This hypothesis remains to be supported by a direct demonstration.
We agree that our conclusions would be even further strengthened by a direct demonstration that DUX4 causes NMD inhibition in primary patient materials, in the absence of ectopic DUX4 expression.
Similar(58)
Yet although the areas responding overall during numerical tasks have been well defined by neuroimaging, a direct demonstration of individual number coding by spatial patterns has thus far been elusive.
For many years the only method recommended for diagnosis was a direct demonstration of hyperglycemia by measuring increased glucose concentrations in the plasma (15, 16).
A direct demonstration is given by the simulation in Fig. 2d, where the maximum of the aggregate receptive field (Eq. 4) is plotted for each point on the column, yielding a Gaussian distribution.
In these circumstances, it is helpful to have a direct demonstration of target engagement by the inhibitor.
Several other studies have suggested that endoscopic surveillance of the bowel greatly reduces colon cancer rates (Table 2), but a direct demonstration that infrequent screening by sigmoidoscopy will reduce mortality requires a large randomised trial.
Although the genetics and cell biology presented were consistent with this conclusion, a direct demonstration of the "handoff" being postulated is needed, perhaps by photoactivation and single particle tracking.
However, no study to date has provided a direct demonstration of the risk of mechanical ventilation requirement as most of the patients included in these studies were not affected by severe forms of bronchiolitis.
This is a direct demonstration in living cells that mRNA deadenylation can specifically contribute to translational repression by a miRNA.
A direct demonstration of the engagement of cytotoxic T lymphocytes in the destruction of tumours mediated by PDT vaccine is provided in the present report.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com