Sentence examples for by a direct binding from inspiring English sources

The present data suggest that the observed downregulation of neurotransmitter release by some but not all protein kinase inhibitors may also be contributed by a direct binding to synapsin I and phosphorylation-independent perturbation of synapsin I function.

These results were confirmed by a direct binding ELISA using wells coated with equimolar concentrations of either Fn or pUC19 DNA and measuring the relative amounts of GST-ComE1 bound (Fig. 2).

Studies in phagocytic cells have shown that Rac1 GTPase plays a key role in activation of the NOX2 NADPH oxidase isoform by a direct binding and recruiting of the p67phox subunit to the membrane [13], [30].

Results from these experiments, however, were negative, indicating that in RAW264.7 cells induction of CD36 expression caused by ritonavir is not mediated by a direct binding of SREBP1c to the CD36 promoter and is likely mediated by activation of additional mechanisms (Figure S3).

The result shows that SH2 domain of Src also directly interacts with phosphorylated Y1057 in a c-Cbl independent manner (Figure 2J), suggesting that the interaction of c-Src with Y1057 of VEGFR-2 is established by a direct binding involving its SH2 domain and an indirect interaction involving c-Cbl.

By a direct binding assay with purified protein, we confirmed that HLA-DRB1*0401 that carries the QKRAA motif is the best hsp73 binder.

Moreover, our functional studies on the mutant DSC2 protein shed light on how the DSC2a isoform may contribute to desmosome and gap junction interdependence by providing a direct binding interface for Cx43.

Interestingly, our findings have provided evidence that ERα may be involved by xenoestrogens without a direct binding activity and produce relevant responses such as ERK phosphorylation, gene expression, and cell growth.

Like ubiquitylation, SUMO conjugation is mediated by a cascade of activating enzyme (E1), conjugating enzyme (E2) and ligase (E3), with Ubc9 acting as the sole E2 and playing a major role in substrate recognition by means of a direct binding motif, ΨKX(D/E) (where Ψ stands for a bulky aliphatic residue: reviewed by [11]).

In NB, we and others have shown that miR-17-92 miR-17-92 miR-17-92tly activatexpression through a disect bindirectlyconserved E-box elements in the miR-17-92 promoter [ 100] (Mestdactivatedrsonal communication; permission was obyained; MYCNdagh P is co-authrough this review).

We recently showed that the WT1 isoform +KTS was able to positively regulates BAG3 expression by a transcriptional mechanism, via a direct binding on two WT1 consensus sites on the bag3 gene promoter.