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Subsequent infection by a different serotype is a risk factor for severe dengue.
Patients that recover from dengue infection by one serotype are at risk of developing severe dengue when infected subsequently by a different serotype.
The second infection was caused by a different serotype in six patients and by the same serotype in 5 patients (Table 3).
Persons previously infected by a DENV serotype may be at higher risk of developing DHF/DSS, if they are subsequently infected by a different serotype.
S. pneumoniae still remained an important risk factor for children who were infected by a different serotype than the ones included in the pneumococcal vaccine.
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Despite a broad immune response, the vaccine is unlikely to confer protection against infection by viruses of a different serotype, and multivalent vaccines are required.
Previous statistical epidemiology studies have found that serotypes compete to some extent for colonisation, as carriage of a certain serotype interferes with subsequent colonisation by pneumococcus of a different serotype [ 5- 10].
DHF and dengue shock syndrome, which is frequently fatal, appear to be more likely after a person is reinfected by unique strains of virus of a different serotype.
DENV infection protects a patient from future reinfection with the same DENV serotype as well as producing temporary immune protection from severe dengue disease caused by a different DENV serotype.
Antibody-dependent enhancement (ADE) has also been implicated, based on observations that re-infection by a different viral serotype increases the risk of severe dengue [ 31].
Increased risk associated with secondary infection by a different DEN serotype is believed to be caused both by increased virus replication resulting from antibody-dependent enhancement and by augmented immune activation induced by the secondary infection [ 3, 4].
More suggestions(15)
by a different measure
by a different organising
by a different coroner
by a different judge
by a different person
by a different idiom
by a different drummer
by a different actor
by a single serotype
by a different forfeiture
by a different company
by a heterologous serotype
by a different burner
by a different character
by a particular serotype
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