These inbred mouse strains have been used as a genetic animal model of depression-like behaviour and are characterized by a different stress-responsiveness, since DBA/2J mice display a stronger behavioural response to stressful conditions [ 22, 23, 29].
In order to compare the effect of Uncl-Sema3E with that of a validated anti-angiogenic molecule, we exploited two metastatic tumour models characterized by different responsiveness to VEGF-targeted anti-angiogenic therapy.
Additionally, we used the ES and the SRM to provide more insight into a potential convergence or divergence in the level of responsiveness by applying these two different responsiveness statistics.
When tested in the physiological context of zebrafish embryogenesis, F331A, W333A and C335A mutations in Wnt3a showed only mild deviations from the wild-type Wnt3a, retaining most of their signaling capacity, which might be due to compensatory effects by a different receptor context and responsiveness of the tissue.
The precise molecular mechanisms by which MM cells show different responsiveness to cladribine remain unclear.
The effect is characterised by a programming of the genome that leads to different responsiveness and adaptability of the gene expression machinery to chronic and acute environmental stimuli, i.e. nutritional supply.
These results suggest that simple IgE- and/or IgG-mediated allergic reaction per se or eosinophilic infiltration in the airway itself may not affect the cough reflex sensitivity or neuropeptide metabolism in guinea pigs, and that cough reflex sensitivity and bronchial responsiveness are modulated by a different mechanism.
In the second phase, methods and experimental conditions were assayed on a cohort of Cambodian women (n = 20), both HIV-positive and healthy subjects, in order to confirm sensitivity and reliability of results on a population characterized by a different genetic background and possibly by a different immunologic responsiveness to HIV. Figure 1 summarizes the design of the whole study.
However, we cannot exclude that mature monocytic progeny of CD33+/CD34+ cells can also maintain p-STAT5 hyper-responsiveness as shown by Kotecha et al. by using a different approach.
It would appear that there is little evidence to suggest a consistently different response to FBT based on pre-intervention physiology, as fluid responsiveness is often tautologically and retrospectively defined by participants' responses to the therapy.
