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These twenty-seven patients were invited for the first visit during which we infused intravenous GTN 0.5 micrograms × kg-1 × minute-1 over 20 minutes to select patients who responded with premonitory symptoms followed by a delayed headache resembling their migraine headache, hereafter referred to as migraine headache [6].
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In addition, GTN causes a delayed headache in cluster headache [3] and migraine patients [4].
In contrast to known headache provoking substances, acetazolamide induced not only immediate but also a delayed headache.
In comparison, sumatriptan induced a contraction of the MMA by 12.3% and reversed the delayed headache attack, but no effects on the MCA were observed.
This interpretation may explain even the delayed headache provoked by vasodilator agents, at a time when vasodilatation has ended.
Further studies showed that in healthy volunteers, the CGRP receptor antagonist, olcegepant, significantly reduced the immediate and delayed headache evoked by CGRP administration [58].
It is possible that extracellular acidosis induced by acetazolamide causes sensitization of cephalic perivascular nociceptors, which, in combination with vasodilatation, leads to delayed headache.
If you've ever had your travel plans disrupted by a flight delayed by three hours or more, you know just how much of a headache it causes.
Differentiating between hangover headache or delayed alcohol-induced headache and usual headache or migraine triggered by alcohol is sometimes difficult in non-migrainous headache and migraine subjects [27].
In other cases aura may be followed by a tension-type headache or even no headache at all.
Migraine aura is generally followed by a migraine headache.
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CEO of Professional Science Editing for Scientists @ prosciediting.com