The fact that TrkB promotes a delayed activation of Tiam1 by phosphorylation does not rule out the possibility that this same receptor could also induce a faster Ras-dependent Tiam1 activation similar to the previously reported for TrkC [19] and to the one showed here for TrkA.
Alternatively, the time delay may be related to a delayed activation of a synchronizing mechanism.
Computer simulation of the mutation suggests a delayed activation.
Also, these cells showed a delayed activation of ATM and Chk2 following exposure to NEU.
The channels remain in a refractory inactivated state until the cell membrane potential repolarizes, normally facilitated by the delayed activation of voltage-gated potassium channels.
The impact cascaded towards impairing downstream apoptosis and the adaptive immune system as the transcripts encoding mitogen-activated protein kinase, TNF receptors and necrosis factors showed temporary suppression, followed by delayed activation induced by LPS insult in spaceflight (Additional file 3: Table S2).
The Na+/H+ exchange function was also affected by hypothermia, with delayed activation of the inward sodium current and more H+ retained intracellularly [5, 6].
In 1993, we proposed a model of mitotic controls in frog eggs and extracts [ 18] that combined the best features of Tyson's and Goldbeter's models, namely, stoichiometric binding of Cdc2 and cyclin B, positive feedback loops through Cdc25 and Wee1, and delayed activation by MPF of the APC.
Therefore it is possible that the differences between study findings on muscle recruitment timing, with some delayed activation observed by Cools et al [ 18], and Wadsworth and Bullock-Saxton [ 20], but not by Moraes et al [ 19], could be due to methodological differences.
This site is known to be essential for the delayed activation conferred on KCNQ1 by KCNE1.
