Sentence examples for by a crystal structure from inspiring English sources

Our data are supported by in vitro site-directed mutagenesis of essential residues as well as by a crystal structure of the protein that became available recently.

In these two cases, the conformation of the ligand in the solid state has been defined in detail by a crystal structure determination.

The peptides competed with native ligands for binding into the conserved hydrophobic groove, as illustrated in detail by a crystal structure of a specific peptide bound to Mcl-1.

Additionally, X-ray diffraction confirmed that the chemical charging process with dissolved oxygen is accompanied by a crystal structure change with the emission of protons and electrons from MnOOH in the same manner as in the electrochemical charging process.

Complexes 3 and 4 were fully characterized including X-ray analysis and 1H NMR spectrum for 4. Reaction of LnCl3 (Ln = Yb, Y) with 2 equiv. of Li2L(THF)0.5 gave the anionic complexes [Li DME 3][LnLn] (Ln = Yb 5, Y 6), which were confirmed by a crystal structure determination.

To further support the interpretation of the residual electron density found above the indole ring of Trp86 in HI-6sarinnonaged-mAChE, we investigated the binding of HI-6 in the corresponding aged enzyme complex (HI-6sarinaged-mAChE) by a crystal structure analysis to a resolution of 2.2 Å (Table 1).

Inhibitor binding at the Thumb-II site was ultimately confirmed by solving a crystal structure of 8b complexed with NS5B.

Here we demonstrate that HOT1 directly binds to telomeric DNA, and characterize this binding in atomic detail by resolving a crystal structure of the HOT1 homeobox domain in a cocrystal with telomeric DNA.

The EGFR–Her2 heterodimer was thus modeled by superimposing a crystal structure of the monomeric Her2 ectodomain (PDB entry 3BE1 [ Bostrom et al., 2009]) onto the ligand-free EGFR subunit in the 1-ligand EGFR dimer using the portion of domain II directly involved in dimerization (EGFR residues 240 309; see 'Materials and methods').

For each fragment identified and validated by this methodology, a crystal structure in complex with the humanised MAYM RadA protein was solved to confirm the binding of that fragment in the Phe pocket.

To define the structural basis of transcription inhibition by GE, we determined a crystal structure of Thermus thermophilus RNAP holoenzyme in complex with GE at 3.35 Å resolution.