We suggest several improvements and indicate that they have to be supported by computational experimentation.
The critical expression level for the gene X is determined empirically through computational experimentation.
Sequencing was performed on approximately 20 40 clones derived from each tissue by ELIM Biopharmaceuticals, Hayward, CA. Because of the large amount of sequence data produced for the study and the risk of sequence contamination or PCR over-representation at the many levels of experimentation, a computational pipeline for screening the entire data base of sequences was developed.
The "citizen science experiment" idea was conceived by Dr John Ashley Burgoyne, a computational musicologist from the University of Amsterdam, and produced by Manchester's Museum of Science & Industry.
Even though such algorithm was tested from a computational viewpoint, up to now, feasibility studies and experimentations are missing.
As in many other biomedical problem areas, a computational approach would here allow diverse experimental results to be absorbed into the formulation of the model, but more importantly, could serve as a hypothesis generator to test mechanisms through further experimentation.
Experience has shown that understanding a computational protocol is based both on inspection of the source code and on experimentation, i.e. observation of the programs' behavior for various input data.
The complexity of such projects however, requires an e-Science approach wherein a computational environment enables transparent and seamless access to distributed datasets, through scientific workflows that automate in silico experimentation across grids of international networks [27].
Consider a computational example.
Until this point, multiple concepts are in place in a situation that is characterized by a high level of experimentation.
