Exact(1)
In line with these results we could demonstrate that episomal enhancer blocking mediated by a composite binding site is sensitive to a poly(ADP ribosylation inhibitor as well.
Similar(59)
An explanation for the ordered binding of Snu13 and Prp31 was provided by structural studies that showed how hSnu13 and the hU4 5′SL provide a composite binding platform for the hPrp31 Nop domain (Liu et al., 2007, 2011), while the mechanism by which hSnu13 leads to enhanced interaction of hPrp3 with U4/U6 di-snRNAs (Nottrott et al., 2002) remained enigmatic.
RETECD envelopes the dimeric ligand complex through a composite binding site comprising four discrete contact sites.
To circumvent this problem, a vector was designed where IL-12 expression was directed by a composite promoter-containing binding motifs for nuclear factor of activated T-cells (NFAT.hIL12.PA2).
Skp2 and Cks1 together form a continuous composite binding site for p27Kip1 that spans both these proteins.
Genes with a high probability of enrichment (FDR ≤0.10) in H3K4me3 or H3K27me3 within the tiled region were used to assemble a metagene of average composite binding.
Our analysis of TF binding motifs in DNA regions identified by ChIP [ 1] showed that ChIP-NANOG regions (isolated with NANOG antibody) had a high abundance of OCT-SOX composite binding motifs also known as HMG/POU cassettes [ 9, 10] (Additional file 7).
The analysis of composite binding motifs revealed the enrichment of E2F-p53 and IRF-p53 composite sites, suggesting the involvement of these two factors in p53-mediated repression of genes on a larger scale than previously anticipated.
They have lost five of their last six games by a composite score of 50-16.
Teams favored by a composite of human polls are 30-21-1 in the same games.
Our Global 2000 ranks companies by a composite of all four of these dimensions.
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