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It is tightly regulated by a complex equilibrium among different pro- and antiangiogenic factors secreted both by tumor cells and by cells of the tumor microenvironment (pericytes, endothelial, mesenchymal or immune cells).
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A complex equilibrium reigns.
The localization of p65 results from a complex equilibrium between cytoplasm to nucleus translocation and nuclear export [10].
This points to a more complex equilibrium that precludes determination of K i.
These new spin systems map to the peptide region that undergoes a complex conformational equilibrium in the free state.
Untangling such a complex conformational equilibrium (summarized in Figure 8) is extremely challenging.
It is solved numerically in the R package Combinatorially Complex Equilibrium Model Selection (ccems) [ 11] by embedding it into a parent system of ordinary differential equations (ODEs) which solves the polynomials at steady state [ 12].
Consequently, in a complex mixture such as whey, the FA will exist in complex equilibrium between the total FA/protein complexes and its free form.
So you get hot content and cold form in complex equilibrium.
The dynamic equilibrium of the continuous reorganization of the actin network is based on its controlled polymerization and depolymerization events, which are guided by a complex interplay of actin with a huge number of regulatory molecules (131 listed in [ 19]).
Plasticity of the almost linear mitochondrial OXPHOS chain is ensured by a dynamic equilibrium between isolated complexes and supramolecular assemblies which is, in turn, influenced by both specific lipids and stabilizing factors (Zhang et al., 2002; Ikeda et al., 2013).
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