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Transcriptional modules represent genes that are regulated by a common regulator.
Biological evidences have showed that some modifications can be regulated by a common regulator and vice versa [ 2, 29].
Intriguingly, in budding and fission yeast, the two additional centromere functions are facilitated by a common regulator DDK, but are regulated independently of each other.
It should be noted that an edge between two nodes does not necessarily indicate a causal interaction between these nodes as it could equally be interpreted as co-regulated expression of both nodes by a common regulator.
On the other hand, the tight packing structure of Hox genes makes it difficult to alter the expression profiles of these genes and to explain how each gene is influenced differently by a common regulator.
Although it has been shown that deletion of SCO2209 does not affect GS activity in S. coelicolor, one cannot exclude the possibility that these genes are controlled by a common regulator.
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Leaders in Brussels and European capitals have pledged to improve budgetary discipline, remove government obstacles to growth and strengthen the banking system by establishing a common regulator at the E.C.B.
The projections onto transcription factors are constructed by linking every two nodes regulating a common gene; similarly, the projections onto regulated genes are built by linking every two regulated genes sharing a common regulator.
This suggests a common regulator activated by the same pathway in both irradiated and bystander cells.
We also found no evidence for modulation of PKC, a common regulator of this phosphorylation site, by ascorbate (data not shown).
Finally, Ca2+ serves as a common regulator of this and other non-classical secretion pathways by promoting vesicular trafficking and/or membrane fusion events [54].
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