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Drug discovery teams classify compounds into chemical series defined by a common core or scaffold.
TRIM (TRIpartite Motif-containing) proteins are characterized by a common core structure (a RING domain, one or two B-box domains, and a coiled-coil region) and accessory domains that make this family diverse at both structural and functional levels [ 3].
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One was to "upgrade state standards by adopting a common core of internationally benchmarked standards".
For example the klymollins [18], extracted from the coral Klyxum molle, are all produced by reactions from a common core molecule and have very similar connectivities and compositions.
Key themes were then discussed by all research teams and a common core of categories agreed to enable comparison together with themes specific to each locality.
MLL1 4 are responsible for methylation at H3K4 and share a common core formed by WDR5, RbBP5, Dpy-30, and Ash2L (Varier and Timmers, 2011).
deviation of 1.6 Å based on 213 superimposed Cα positions, this value dropping to 0.77 Å when considering a common core defined by 142 Cα positions (see Figure 1C).
These splicing variants share a common core peptide, flanked by varying termini (Class 1 and 2 N-terminal peptides, and E peptides).
Each holoenzyme comprises of a common core enzyme formed by the scaffold (A) and catalytic (C) subunits (two isoforms each) that recruits a variable regulatory subunit derived from four different families (B/B55/PR55, B′/B56/PR61, B″/PR72, and B″′/Striatin).
Fortunately, underlying the many idiosyncratic qualifications and variants of the position, there exists a common core of ideas, typified by an epistemically positive attitude towards the outputs of scientific investigation, regarding both observable and unobservable aspects of the world.
In particular, a common core can be identified, composed by β4, β4-α4, and α4 residues, together with the β3-α3 region.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com