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Thus the total number of distinguishable ways you can distribute balls into the boxes is for the CBB-model reduced by a combinatorial factor <img src="http://journals.plos.org/plosone/article/asset?id=info?doi/10.1371/journal.pone.0001690.e004.PNG" class= inline-graphic"/> (more details in Supporting Information Text S1).
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When the binding of any individual factor was eliminated by a site-specific mutation, transcriptional activity was reduced, but not abolished, indicating that the overall transcription efficiency is determined by a combinatorial effect of multiple factors.
Mammalian enhancers can be defined by a combinatorial code for an assembly of transcription factor binding sites (TFBS), but in silico identification has proven difficult.
The essence of language is words and syntax, each generated by a combinatorial system in the brain.
Many functional categories are specifically influenced by a combinatorial effect.
The silkworm OBPs could play a chemosensory role in chemoreception by a combinatorial interaction with chemoreceptors.
These combinatorial factors do usually not allow to find a concise biological interpretation.
Similarly, an analyst can identify the optimal medium for culturing a particular cell (iPS or cancer cell) using an MMV of a combinatorial set of factors (generated by the 2N method).
The functional form and corresponding parameters are determined element-wise by solving a combinatorial optimization problem.
We hypothesized that the regulation of the ERα-dependent/cAMP-regulated genes might be explained by a simple combinatorial code of transcription factor co-recruitment that could be detected by analyzing the promoter/enhancer regions of these genes.
We also showed from the different ChIP-seq data that phase regulation of transcription of circadian genes is driven by specific transcription factors in a combinatorial manner consistent across multiple tissues.
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