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Mammalian enhancers can be defined by a combinatorial code for an assembly of transcription factor binding sites (TFBS), but in silico identification has proven difficult.
Since mammals can detect far more than 1000 odors (Duchamp-Viret et al., 1999; Rubin and Katz, 1999), this suggests that olfactory information at this level is encoded by a combinatorial code (Malnic et al., 1999).
More specifically, in both vertebrates and Drosophila, motorneuron subtype identity is determined by a combinatorial code of Lhx genes and a particular Lhx gene defines interneuron subtype identity, suggesting that these genes played such roles in the common ancestor of bilaterians [ 23, 27- 29].
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Pique, M., Lopez, J. M., Foissac, S., Guigo, R. & Mendez, R. A combinatorial code for CPE-mediated translational control.
Thus, in both vertebrates and invertebrates, the cells of the neuroectoderm acquire unique spatial information in the form of a combinatorial code of gene expression, which is conferred by embryonic patterning genes.
If a combinatorial code governing splice site selection exists, the solution will likely emerge through interdisciplinary approaches merging computational methods with biochemical and functional genomics approaches.
Together, these results show that a combinatorial code of activity across multiple neurons is essential to drive plasticity in an animal's behavior to BZ odor.
Odorants are thought to be recognized by matching a specific spatial pattern (a combinatorial code) [5].
Collectively, these studies raised the possibility that post-translational modifications of histones, such as sumoylation, methylation, and acetylation, could form a combinatorial code recognised by specialised proteins referred to as readers of the epigenetic code, which in turn would regulate transcription of genes that prevent hyperactivation of the LET-60 signalling pathway.
A combinatorial code of neuropeptides acts on the circuit to regulate both valence and sensitivity.
The activation of DMA-1 strictly requires all three ligands, which establishes a combinatorial code to precisely target and pattern dendritic arbors.
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