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Serpinb12 gained an extra exon and was duplicated to give rise to the 8-exon genes, followed by a chromosomal split yielding two loci.
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Here, we use the completed chicken genome to show that the two mammalian loci are the result of an ancient chromosomal split, as orthologues of genes from both human loci are linked in the chicken.
These observations indicate that the linked arrangement found in Ciona savignyi might have been split by a chromosomal rearrangement in Ciona intestinalis.
disrupted by a chromosomal inversion from hpp12_92 to hpp12_128.
Evidence of repeated chromosomal splits is found in mammalian evolutionary courses towards specialization.
The Osiris gene family was also found in the mosquito Anopheles gambiae, maintaining the synteny except for a chromosomal rearrangement that split the cluster (Dorer et al. 2003).
The latter genes were further split into two loci by the insertion of a chromosomal region flanked by LIPE and CD79A.
In the 2nd split pancreas branches off (high influence of insulin), followed by a 3rd split branch formed by pituitary, ovary, and adrenal gland.
In addition, in strain 26695 this segment had been split in two by a large chromosomal inversion.
More generally, any set of splits Σ can always be represented by a split network N (Dress and Huson, 2004).
In late 1929, the party was weakened by an internal split.
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