UBE3A functions as a cellular quality control ubiquitin ligase.
Therefore, it has been suggested that UBE3A also functions as a cellular quality control ubiquitin ligase.
Also, for elucidating the unfolded protein response, a cellular quality-control system that detects disease-causing unfolded proteins and directs cells to take corrective measures.
For elucidating the unfolded protein response, a cellular quality-control system that detects disease-causing unfolded proteins and directs cells to take corrective measures.
Proteins serve in cellular roles that necessitate structural precision, a requirement overseen by the cellular quality control system (QCS).
This latter finding might be explained by the elimination of misfolded CFTR by cellular quality control mechanisms.
Misfolded proteins that were destined for lysosomes accumulate in the ER, and these are rapidly degraded by the cellular quality control machinery [45].
How red cells accomplish this is not known, but we believe it is one manifestation of a general cellular quality control mechanism, which may have broader implications for human disease.
Misfolded proteins are generally recognised by cellular quality control machinery, which typically results in their ubiquitination and degradation.
Proteins that do not fold correctly or older proteins that exceed their functional lifetime are recognized by cellular quality control mechanisms that target them for degradation.
