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Importantly, these changes in morphology were reflected by a biphasic pattern of microtubule dynamics.
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Stimulation by glucose induces a biphasic pattern of insulin release.
Physostigmine release from the microparticles showed a biphasic pattern, characterized by an initial burst release followed by a sustained release for PLGA 65 35, PLGA 50 50 and RG 502 or a non-detectable release for PLGA 85:15, PLGA 75:25 and PLA.
The release behavior of paclitaxel from the polymer matrix exhibited a biphasic pattern characterized by a slow initial release during the first 26 days (less than 10% paclitaxel), followed by a faster and uniform release (the accumulative amount of paclitaxel released in 92 days was between 17 and 44%).
By contrast, the transcript accumulation of PP2A3&4 exhibited a biphasic pattern.
A biphasic pattern of Ca2+ was reported by [ 20] whereas [ 21] infused the total amount of Na2EDTA over a 20-min period and found the drop in plasma total calcium approached a linear curve.
A non-compartmental analysis of the pharmacokinetics graph indicates a biphasic pattern with initial rapid phase followed by a slower decay of Pax with the level falling beyond detection limit by 48 h.
LTA stimulation, on the other hand, resulted in a biphasic pattern with an early peak followed by return to baseline and a secondary peak at a later time point).
Afterwards, it was established that elution of antibiotics from acrylic cement follows a biphasic pattern, with high elution rates early, followed by slower but sustained elution rates as time progresses [ 8].
In case-patient 3, the illness exhibited a biphasic pattern with a brief resolution of fever, followed by the return of high temperature and progression of respiratory and chest x-ray changes.
The drug was released from the NPs in a biphasic pattern with an initial burst release (32.1 %) followed by sustained release (53 %) at the end of 5 d.
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