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The outer bristle organ is derived from the pIIa daughter cell, which is generated by a Notch dependent unequal division of the sensory organ precursor cell (Fig. 5A).
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A positive feedback-loop between boundary and non-boundary cells and mediated by the activities of Notch and Wingless/Wnt-1 leads to the establishment of a Notch dependent organizer at the boundary.
The overexpression of Upd in ept mutant cells has also been shown to occur by a Notch-dependent mechanism [6].
However, exposure of UC cell lines to immobilized DLL1, which is considered to yield superior activation compared to soluble ligand [ 26] did not enhance activation of a Notch-dependent reporter by transfected NOTCH1 protein, least activate canonical signalling by itself.
Thus, Hes1 expression results from both a Notch-dependent and a Notch-independent signalling in intestinal tumorigenesis.
The Notch target gene HES1 is upregulated in RMS and prevents tumour cell differentiation in a Notch-dependent manner.
Thus, Shh induces cHairy2 in the neuroepithelium in a Notch-dependent manner.
This decision depends on Notch signaling: ISCs produce the Notch ligand Delta, which activates a Notch-dependent transcriptional program in the EB leading to its differentiation into an EC (Ohlstein & Spradling, 2006, 2007; Bardin et al, 2010).
We show that new crystal cells in third instar larvae originate through a Notch-dependent process of plasmatocyte transdifferentiation.
Notably, ShhN also induced Hes1 expression in a Notch-dependent fashion, supporting the I-LNP data (Fig. 2B).
Since loss of grl function resulted in fewer etsrp+ cells, we hypothesized that constitutive activation of Notch dependent transcription by injecting notch-intracellular domain (notchICD) mRNA should increase numbers of these cells.
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