Among the different genes listed, we confirmed that DKK1 was expressed in breast cancer cells, with restricted expression in the placenta.
CT antigens, with restricted expression in normal gametogenic tissues and aberrantly expressed in a wide range of cancers, are considered to be ideal targets for cancer vaccination today.
SLAMF7, a member of the immunoglobulin (Ig) gene superfamily, is highly expressed on the surface of MM cells with restricted expression on specific lymphocytes including resting natural killer (NK) cells, NKT cells, CD8+T cells, activated monocytes, and activated B cells [ 21].
Oncofetal antigens and melanoma associated antigens represent those with restricted expression in non-malignant tissues, whereas cancer testis antigens are only expressed, as the name suggests, in the tumor and in testes, with testes being protected by mechanisms of immune privilege.
To test whether the present dataset can be used for the identification of genes with restricted expression signatures, signal intensity data was subjected to stringent filtering schemes.
Genome-wide data are provided in sagittal sections, and coronal sections for about 4000 genes with restricted expression patterns are also provided.
Several families of genes with restricted expression to the heart have been identified in the last years, including genes encoding for contractile proteins, ion channels as well as transcription factors involved in tissue specific gene expression.
For example, Atoh1 expression progressively reduced in the wild-type cochlea from base-to-apex started from P0 to onward with restricted expression only in the inner two rows of OHCs (Fig. shown'; shown in P0).
To delineate the cellular mechanism by which OAMB regulates ovulation, we explored protein kinases functionally interacting with OAMB by employing a new GAL4 driver with restricted expression in the oviduct epithelium.
In this study, we initially set out to determine the evolutionary origin of the MS4A and TMEM176 families, which include several genes encoding proteins with restricted expression in the immune system.
