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It is also noteworthy that the genes on the scatter plots are more equally distributed for mRNA-Seq vs proteome comparison (left bottom corner) whereas, in particular for Febit arrays, a bias was observed towards genes that are highly expressed on the arrays but with low expression on the proteome-map.
Samples with GC positivity up to 40%, but with low expression levels (1+) were also detected only in TCs.
The other mitochondrial genes ND2, ND3, ND5, ND6, COX2 and COX3 were moderately down regulated but with low expression values (fold changes between -1.31 and -1.85).
As a control we examined the expression pattern of spiny dogfish TCRα and saw its expression pattern differed from that of SaCD79α and the Ig heavy chains, in this case being most highly expressed in spleen, gill and blood (N.B. thymus material was not available for examination in this experiment) but with low expression in epigonal and Leydig organs (Fig. 6E).
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The AP-2 binding site (GCTGCAGGC) at -213 to -221 was originally identified as a DNase I footprinted site that was protected by nuclear extracts from ERBB2 over-expressing cells (but not those with low expression), indicating differential DNA-binding activity of a nuclear factor, which was termed OB2-1.
The amount of starting mRNA is not only significantly conserved, but also genes with low expression level are detectable after amplification.
VEGF-A was a powerful poor prognosticator in patients with high tumor cell Ang-2 expression, but not in those with low expression.
A second study reports a significant association between MAOA and happiness, but only in women, with low expression being related to greater happiness (Chen et al. 2013).
The investigators also discovered that histone desacetylase inhibitors induced breast CSC differentiation but only in tumors with low expression of long non-coding RNA XIST, suggesting the potential of XIST as a predictive biomarker [ 4].
Genes highly expressed in melanoma, but not in melanocytes (or with low expression levels) were listed.
Patients with high telomerase expression had higher risk of disease recurrence and death than those with low expression, but the elevated risks were not statistically significant.
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