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Overall, conclusions reached by RCCTs in unselected patients may be appropriate if the therapy hits a target present in most patients, but will be problematic for drugs hitting less common targets.
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But achieving this 'universality' will be problematic given the difficulties in providing consistently high-quality healthcare in complex sociotechnical systems.
Still, he says, "There are certainly vulnerable people, very poor people in very poor places—[but] there is a second group for whom the situation will be problematic but manageable".
But experts say raising finance for infrastructure projects will be problematic worldwide and will be challenging in Africa.
Sampras has said he doubted the climb from 12 Grand Slam titles to 15 will be problematic for the 26-year-old Federer, but isn't it fascinating how Sampras, retired since 2002, restrung his rackets and recalibrated his serve just as Federer closed in?
But any journey by Serena and Venus Williams to the women's final will be problematic for both, especially for the 10th-seeded younger sister, Serena.
Playing Argentina is a problem any time because they are a good team but I think there's definitely going to be climatic conditions which will be problematic for teams, not least of all the northern European sides.
"If you go into one store and pay with one technology, but are not able to use that technology in another store, clearly that will be problematic".
This will be problematic.
It will be problematic for gas supplies to Western Europe.
The Casey test will be problematic if it constrains -- and obfuscatory if it does not.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com