The lack of a gp70-related infection deficit could conceivably reflect that another virion glycoprotein also binds strongly to GAGs, but the weak binding of gp150 seemed unlikely to fulfill such a role.
Our results validate the premise that stereospecific but necessarily weak binding of tropomyosin to F-actin is required for effective thin filament function.
IP analysis confirmed the lack of interaction between DAP5 and eIF4E/PABP, but strong interaction with eIF3d (and FXR1/2, FMR1) compared to weak binding of eIF3d to eIF4GI, and only very weak binding to eIF4GII.
In addition to Id1, Id3, Tcf15, Twist1, and NeuroD1, we also confirmed protein inhibitor of activated STAT factors Pias1, Pias2, and Pias4, and homeodomain-interacting protein kinase Hipk2, as true but weaker binding partners of E47 and E12.
Similarly, for reversibility, weak binding of the dopant to the lattice and escape back into the environment is important.
While it may be expected that residues in the catalytic domain would undergo protection from exchange with solvent upon substrate binding, this lack of perturbation may be due to weak binding of the acetylated substrate peptide, consistent with its high Km measured (Fig. 2b, Table 2).
Electron doping via splitting of H2 into protons and electrons results in the reduction of several Ni sites to Ni2+, which is verified by X-ray spectroscopy, causing a large decrease in conductance, which can be reversed due to the weak binding of the dopant with the lattice.
The rate of silica production was slower for H2SO4 than HCl or HNO3 due to weak binding of the SO4−2 counterion to CTA+ surfactant according to the Hofmeister series [45].
