Specific concerns regarding their sustainability include personnel costs, as well as the variability and variable efficacy of these models [ 18].
In April 2009, WHO strongly recommended the introduction of rotavirus vaccines into national immunisation programmes worldwide, but noted a need for ongoing monitoring of vaccine performance on the basis of variable efficacy of the vaccines in different populations.
Cases reports and small series of patients with C3 glomerulopathy have reported variable efficacy of eculizumab.
There have been multiple explanations put forward to try to explain the variable efficacy of the BCG vaccine.
The increasing prevalence of resistance to chemical acaricides and variable efficacy of current tick vaccine candidates highlight the need for more effective control methods.
These NMR probes provided insight into the role of Asp522.50 as an allosteric link between the orthosteric drug binding site and the intracellular signaling surface, revealing strong interactions with the toggle switch Trp 2466.48, and delineated the structural response to variable efficacy of bound drugs across A2AAR.
The variable efficacy of Na+ channel blockers in infants with the R1623Q mutation is particularly important in view of the fact that cellular biophysical and pharmacological studies showed effective restoration of channel function of this mutation by lidocaine[29].
tuberculosis) mediated mortality and morbidity continue to rise with the emergence of extremely-drug resistant bacteria, co-infection with HIV and variable efficacy of protection offered by M. bovis Bacillus Calmette-Guerin (BCG) vaccine [1], [2].
Concerns about the variable efficacy of these drugs and the possible development of resistance [3], [10], [12] have stimulated efforts to develop new methods of control, including vaccines [13], [14], [15], [16], [17].
The most widely accepted explanation for the variable efficacy of BCG in many global trials is that prior exposure to environmental mycobacteria either inhibits the replication and development of BCG induced protective immune response or masks the effect of BCG vaccination by providing a similar degree of anti-mycobacterial immunity [11], [33].
