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Although high recurrence of HCC is the major challenge but variable degree of benefit has been observed by use of chemotherapeutic agents such as interferon [ 5, 6].
This variability is illustrated by the recent findings from Koeffler and co-workers showing that vorinostat produced a profound but variable degree of inhibition of proliferation of lymphoma and leukaemia cells, including Burkitt, B-cell acute lymphoblastic leukaemia (B-ALL), MCL, DLBCL, ATL and T-cell (Sakajiri et al, 2005).
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Even within the same patch, there is often significant but variable degrees of selectivity with respect to forage species (Manser and Brotherton 1995), phenological status of plant (Hiernaux and Turner 1996), plant part (Ayantunde et al. 1999), and physiological state of plant as affected by nutrient and moisture availability (Belsky 1986; McNaughton and Georgiadis 1986).
Increased but variable degrees of CO2 outgassing and steam (bubble) formation during thermal fluid flow are also strongly suggested by the analyzed C and O isotopic distribution and evolution in the carbonate scale-fragments (Fig. 6; Additional file 1: Tables S3, S4).
The uptake intensity of radiolabeled analogs of somatostatin, FDOPA and FDG can vary in different lesions in the same patient mainly reflecting the tumor heterogeneity but also a possible variable degree of tumor differentiation (Fig. 5).
Bone marrow was always infiltrated but there was a highly variable degree of infiltration (10 90%, median 25%).
RT-PCR showed that AOs that annealed to the area around the exon 12 donor site did induce the Δ150 lamin A transcript, but most AOs also caused a variable degree of exon 11 skipping.
In vivo, some ookinetes showed a variable degree of labeling but 80 90% ookinetes were not labeled at 22 24 h (Figure 2A).
At retrieval, all the implants were characterized by variable degree of stenosis, but the engineered constructs showed full epithelialization, increased levels of α-elastin and collagen, and decreased GAG content pre- and postoperatively.
Ultimately the abnormal pressure damages the retina and causes a variable degree of blindness.
Heterogeneity in the response to botulinum toxin suggests a variable degree of cholinergic preservation of individual achalasia patients.
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