True positives (TP) were defined as experimentally validated in-silico predictions; false negatives (FN) are the experimentally validated interactions but not predicted in-silico, and the false positives (FP) are defined as in-silico predictions that were not experimentally validated.
Estimated creatinine clearance formulas (sMDRD, CKD-EPI, Cockroft and Gault) must not be used because they were developed for stable patients with chronic renal insufficiency (CRI), but not validated in critically ill patients [2].
A similar scale, the Faces Pain Scale, developed for use in pediatric populations, but now validated in all age ranges, may be particularly helpful in patients who are illiterate or have language difficulties [ 23- 27].
Initially, eQTL were identified in the first replicate with a p-value cut-off of 1E-6 (Additional File 1) but were validated in replicate 2 with a less stringent cut-off of 1E-5 [ 21].
Significantly, all events but one validated in both the GP3 and GP4 samples; however, the intensity of the bands often varied between GP3 and GP4, indicating this did not result from LCM contamination.
Because of linguistic difference and cross-cultural issues, OHRQoL instruments must not only be translated but also validated in the target population prior to cross-cultural and cross-national adaptation [ 27- 30].
In addition, we detected one locus that was mentioned, but not further validated in the initial publication: a small, but still significant region on chromosome II (referred to in this study as QTL4 encompassing 18 of the marker sites).
OBJECTIVE: The use of cross-sectional area (CSA) measurements obtained from computed tomographic angiography (CTA) for the calculation of carotid artery stenosis has been suggested but not yet validated in a large population.
But Gethard was validated in his belief that he lives in a world where not only would Diddy see his original YouTube video, but agree to perform at a small improv theater solely based on the tenacity and enthusiasm of Gethard and his friends and fans.
Thirdly, five more prediction models have been developed but were not validated in this study.
