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In fields such as structural biology, expression of more stable sub-full-length protein constructs is a common strategy, but this necessitates prediction of domain boundaries in order to design constructs.
Search strategies may need to be over-inclusive so as not to miss any potentially relevant records but this necessitates a time consuming and costly process of screening for very small return.
Enriching study populations with rapidly progressing patients may offset some of this effect, but this necessitates the availability of prognostic markers that can accurately identify which patients are most likely to develop erosive damage and functional disability.
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But this necessitated a profound row and, some say, a lasting rift with the Catholic church, which he had already taken on with his same-sex marriage legislation when he first took office.
The development of both metallic and polymer stents has resulted in better functioning devices that can be removed more easily but this still necessitates some kind of procedure.
(Some animal rights advocates promote allowing domesticated farm animals being allowed to live out their natural lives but not furthering their procreation, but this also necessitates an allocation of resources as well as perceived sacrifice by humans).
Targeted single-cell mutation detection is also likely to reduce error rates, but this methodology necessitates knowledge of the specific mutations carried by a particular tumour.
Our observations indicate that fusion of SUMO-1 to a peptide-PTD module allows generation of a stable hybrid protein that is easily produced in bacteria and which efficiently enters into cells but this property necessitates mutation of the diglycine motif at the end of SUMO-1, thereby impairing delivery of the peptide alone.
This necessitates getting close but you can do it in a teasing manner, such as standing over them as they sit.
But the very expense of productions like this necessitates a long period of amortization, whatever the artistic merits.
This necessitates not only inter-organizational collaboration but also inter-organizational performance measures.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com